Male Amargosa Toads tend to be smaller than females. Females will lay up to 6,000 eggs in long strands. They will typically lay their eggs along the edge of slow streams, among vegetation, and in shallow bodies of water. The eggs will develop and hatch into tadpoles faster in warmer water. The tadpoles need open water for their development.
Adult Amargosa Toads do the majority of their foraging at night. They use their sticky tongues to catch their prey. Their prey includes many different types of invertebrates such as spiders, snails, insects, and even scorpions. During the daytime these toads take shelter from the desert heat in burrows, under dense vegetation, and in piles of debris.
This species is incredibly rare and threatened by several factors. Given that they are a desert dwelling toad, water is a precious and finite resource. Water diversion and the degradation of their wetland habitats threaten the toads as well as several invasive species including bullfrogs and crayfish.